Fossati and colleagues (2009) performed a systematic review of randomized clinical trials in metastatic breast cancer reported between 1975 and 2009 that were identified by a MEDLINE and EMBASE search. The data extracted from each report included tumor response, the hazard ratio for mortality, and proportion of patients with severe side effects. A total of 189 randomized trials was identified, of which all provided response data and 133 (70%) provided data or Kaplan-Meier ...